With the heads of the Detective Agency and the Port Mafia hospitalized due to a deadly virus, a one-on-one battle between Akutagawa and Kyouka, and Chuuya and Ranpo threatens to wreak havoc on the city of Yokohama!

Meanwhile, Kunikida and Atsushi are in desperate search for a cure, but will they make it in time or be forced to fight their old nemesis once more?!